Fig. 5
From: Antiarthritic activities of berberine in a rat model of gouty arthritis
Effect of treatment on MSU-induced pathological changes in paw (ankle) joints in different experimental groups: (a) Photomicrograph, articular surface of negative control group showing normal histological structure (arrows) (H&E, scale bar 100 µm). (b) Photomicrograph, subcutaneous tissue showing infiltration of mononuclear inflammatory cells (arrow) in MSU-induced paw (H&E, scale bar 100 µm). (c) Photomicrograph, rat paw showing irregularity of articular surface (arrow) in MSU-induced paws (H&E, scale bar 100 µm). (d) Photomicrograph, articular surface showing necrosis of chondrocytes (arrows) in MSU-induced paws (H&E, scale bar 100 µm). (e) Photomicrograph, MSU-induced paw treated with BERB (50 mg/kg/day) showing smooth articular surface (arrows) (H&E, scale bar 100 µm). (f) Photomicrograph, MSU-induced paw skin treated with BERB (50 mg/kg/day) showing mild infiltration of mononuclear inflammatory cells (arrow) (H&E, scale bar 100 µm). (g) Photomicrograph, MSU-induced paw treated with Para (50 mg/kg/day) showing mild edema of synovial membrane (arrow) (H&E, scale bar 100 µm). (h) Photomicrograph, MSU-induced paw treated with Para (50 mg/kg/day) showing smooth articular surface (arrows) (H&E, scale bar 100 µm).
