Table 1 Incorporating basic demographic information and clinical characteristics of the population, based on the MIMIC-IV database.
Variable | ICU-day | 28-day | ||||
---|---|---|---|---|---|---|
Survivors | Non-survivors | p value | Survivors | Non-survivors | p value | |
N | 833 | 119 | 744 | 208 | ||
Age (years) | 73.26 ± 11.76 | 75.29 ± 10.40 | 0.074 | 72.66 ± 11.60 | 76.59 ± 11.19 | < 0.001 |
Gender, (%) | 0.901 | 0.201 | ||||
Female | 341 (40.94%) | 48 (40.34%) | 296 (39.78%) | 93 (44.71%) | ||
Male | 492 (59.06%) | 71 (59.66%) | 448 (60.22%) | 115 (55.29%) | ||
BMI, (kg/m2) | 29.52 ± 8.35 | 29.98 ± 7.96 | 0.568 | 29.76 ± 8.44 | 28.89 ± 7.74 | 0.181 |
WBC, (K/uL) | 11.93 ± 6.14 | 13.30 ± 5.50 | 0.021 | 11.88 ± 5.77 | 12.88 ± 7.02 | 0.036 |
PLT, (K/uL) | 204.86 ± 89.04 | 210.61 ± 82.34 | 0.506 | 206.54 ± 89.83 | 202.15 ± 82.25 | 0.526 |
HGB, (mg/dL) | 11.71 ± 2.32 | 11.04 ± 2.35 | 0.003 | 11.75 ± 2.30 | 11.21 ± 2.39 | 0.004 |
Albumin, (g/dL) | 3.23 ± 0.54 | 3.09 ± 0.54 | 0.010 | 3.24 ± 0.54 | 3.12 ± 0.51 | 0.006 |
Sodium, (mEq/L) | 138.53 ± 5.52 | 138.08 ± 6.58 | 0.425 | 138.45 ± 5.58 | 138.55 ± 5.94 | 0.815 |
Potassium, (mEq/L) | 4.19 ± 0.76 | 4.35 ± 0.96 | 0.036 | 4.18 ± 0.77 | 4.31 ± 0.87 | 0.040 |
Calcium, (mg/dL) | 8.46 ± 0.88 | 8.46 ± 0.80 | 0.979 | 8.47 ± 0.88 | 8.41 ± 0.82 | 0.406 |
Chloride, (mEq/L) | 102.78 ± 6.60 | 102.42 ± 7.48 | 0.590 | 102.65 ± 6.62 | 103.00 ± 7.07 | 0.506 |
Lactate, (mmol/L) | 1.97 ± 1.44 | 2.63 ± 2.05 | < 0.001 | 1.96 ± 1.48 | 2.37 ± 1.71 | < 0.001 |
TG, (mg/dL) | 149.02 ± 165.83 | 165.87 ± 186.97 | 0.308 | 149.67 ± 163.94 | 156.35 ± 184.66 | 0.614 |
Cholesterol, (mg/dL) | 137.26 ± 33.62 | 126.80 ± 36.95 | 0.002 | 137.77 ± 33.62 | 129.44 ± 35.55 | 0.002 |
HDL, (mg/dL) | 41.56 ± 14.60 | 40.23 ± 13.52 | 0.351 | 41.23 ± 14.17 | 41.97 ± 15.54 | 0.516 |
LDL, (mg/dL) | 72.41 ± 26.59 | 64.15 ± 25.53 | 0.001 | 72.98 ± 26.45 | 65.62 ± 26.34 | < 0.001 |
ALT, (IU/L) | 104.03 ± 390.68 | 159.10 ± 539.98 | 0.173 | 108.20 ± 412.54 | 120.64 ± 412.59 | 0.701 |
AST, (IU/L) | 161.30 ± 660.54 | 245.69 ± 737.94 | 0.199 | 171.35 ± 696.43 | 173.63 ± 571.66 | 0.965 |
BUN, (mEq/L) | 28.23 ± 21.50 | 34.82 ± 21.93 | 0.002 | 27.69 ± 20.74 | 33.93 ± 24.07 | < 0.001 |
CR, (mg/dL) | 1.45 ± 1.39 | 1.70 ± 1.36 | 0.071 | 1.44 ± 1.40 | 1.62 ± 1.34 | 0.105 |
LD, (IU/L) | 478.70 ± 916.93 | 612.70 ± 789.00 | 0.130 | 498.51 ± 979.99 | 484.53 ± 543.91 | 0.844 |
CK, (IU/L) | 1051.65 ± 7407.49 | 1253.17 ± 3076.40 | 0.770 | 1107.54 ± 7824.40 | 967.03 ± 2489.66 | 0.799 |
Ventilation_hour | 125.38 ± 138.13 | 187.48 ± 191.58 | < 0.001 | 133.79 ± 154.61 | 130.82 ± 117.22 | 0.797 |
HbA1c, (%) | 6.23 ± 1.32 | 6.31 ± 1.63 | 0.523 | 6.25 ± 1.35 | 6.20 ± 1.42 | 0.694 |
HGI | 0.01 ± 1.15 | − 0.12 ± 1.35 | 0.261 | 0.04 ± 1.16 | − 0.15 ± 1.23 | 0.038 |
SHR | 1.17 ± 0.38 | 1.29 ± 0.44 | 0.003 | 1.16 ± 0.35 | 1.27 ± 0.49 | < 0.001 |
GV | 17.04 ± 10.29 | 20.75 ± 10.63 | < 0.001 | 16.82 ± 10.04 | 19.93 ± 11.30 | < 0.001 |
Hypertension, (%) | 0.242 | 0.820 | ||||
No | 485 (58.22%) | 76 (63.87%) | 437 (58.74%) | 124 (59.62%) | ||
Yes | 348 (41.78%) | 43 (36.13%) | 307 (41.26%) | 84 (40.38%) | ||
Diabetes, (%) | 0.114 | 0.922 | ||||
No | 538 (64.59%) | 68 (57.14%) | 473 (63.58%) | 133 (63.94%) | ||
Yes | 295 (35.41%) | 51 (42.86%) | 271 (36.42%) | 75 (36.06%) | ||
Heart Failure, (%) | 0.941 | 0.614 | ||||
No | 416 (49.94%) | 59 (49.58%) | 368 (49.46%) | 107 (51.44%) | ||
Yes | 417 (50.06%) | 60 (50.42%) | 376 (50.54%) | 101 (48.56%) | ||
Chronic Kidney Disease, (%) | 0.019 | 0.825 | ||||
No | 636 (76.35%) | 79 (66.39%) | 560 (75.27%) | 155 (74.52%) | ||
Yes | 197 (23.65%) | 40 (33.61%) | 184 (24.73%) | 53 (25.48%) | ||
Acute Kidney Injury, (%) | < 0.001 | 0.001 | ||||
No | 447 (53.66%) | 40 (33.61%) | 401 (53.90%) | 86 (41.35%) | ||
Yes | 386 (46.34%) | 79 (66.39%) | 343 (46.10%) | 122 (58.65%) | ||
Hyperlipidemia, (%) | 0.106 | 0.030 | ||||
No | 389 (46.70%) | 65 (54.62%) | 341 (45.83%) | 113 (54.33%) | ||
Yes | 444 (53.30%) | 54 (45.38%) | 403 (54.17%) | 95 (45.67%) | ||
Ventilation, (%) | 0.474 | 0.904 | ||||
No | 80 (9.60%) | 9 (7.56%) | 70 (9.41%) | 19 (9.13%) | ||
Yes | 753 (90.40%) | 110 (92.44%) | 674 (90.59%) | 189 (90.87%) | ||
HbA1c, group (%) | 0.344 | 0.832 | ||||
Q1 | 177 (21.25%) | 29 (24.37%) | 158 (21.24%) | 48 (23.08%) | ||
Q2 | 244 (29.29%) | 26 (21.85%) | 211 (28.36%) | 59 (28.37%) | ||
Q3 | 182 (21.85%) | 31 (26.05%) | 171 (22.98%) | 42 (20.19%) | ||
Q4 | 230 (27.61%) | 33 (27.73%) | 204 (27.42%) | 59 (28.37%) | ||
HGI, group (%) | 0.005 | 0.010 | ||||
Q1 | 194 (23.29%) | 44 (36.97%) | 170 (22.85%) | 68 (32.69%) | ||
Q2 | 219 (26.29%) | 19 (15.97%) | 199 (26.75%) | 39 (18.75%) | ||
Q3 | 211 (25.33%) | 26 (21.85%) | 183 (24.60%) | 54 (25.96%) | ||
Q4 | 209 (25.09%) | 30 (25.21%) | 192 (25.81%) | 47 (22.60%) | ||
SHR, group (%) | < 0.001 | < 0.001 | ||||
Q1 | 212 (25.45%) | 26 (21.85%) | 195 (26.21%) | 43 (20.67%) | ||
Q2 | 217 (26.05%) | 21 (17.65%) | 198 (26.61%) | 40 (19.23%) | ||
Q3 | 216 (25.93%) | 22 (18.49%) | 188 (25.27%) | 50 (24.04%) | ||
Q4 | 188 (22.57%) | 50 (42.02%) | 163 (21.91%) | 75 (36.06%) | ||
GV, group (%) | < 0.001 | < 0.001 | ||||
Q1 | 225 (27.01%) | 13 (10.92%) | 209 (28.09%) | 29 (13.94%) | ||
Q2 | 208 (24.97%) | 30 (25.21%) | 184 (24.73%) | 54 (25.96%) | ||
Q3 | 205 (24.61%) | 33 (27.73%) | 182 (24.46%) | 56 (26.92%) | ||
Q4 | 195 (23.41%) | 43 (36.13%) | 169 (22.72%) | 69 (33.17%) |