Table 2 Multivariable Cox regression analysis of ICU and 28-day all-cause mortality in the HbA1c group, HGI group, SHR group, and GV group.

From: To explore the relationship between multiple glycemic markers and all-cause mortality in patients with severe atrial fibrillation based on multiple databases

Outcomes Exposure

Model 1

HR (95% CI, P)

Model 2

HR (95% CI, P)

Model 3

HR (95% CI, P)

ICU mortality

   

HbA1c group

   

Q1

Ref

Ref

Ref

Q2

0.7 (0.4, 1.2) 0.222

0.7 (0.4, 1.2) 0.159

0.7 (0.4, 1.3) 0.264

Q3

1.1 (0.7, 1.9) 0.617

1.2 (0.7, 2.0) 0.577

1.3 (0.7, 2.2) 0.398

Q4

0.8 (0.5, 1.2) 0.267

0.6 (0.3, 1.1) 0.088

0.6 (0.3, 1.1) 0.097

HGI group

   

Q1

Ref

Ref

Ref

Q2

0.5 (0.3, 0.9) 0.012

0.5 (0.3, 0.8) 0.009

0.5 (0.3, 0.8) 0.010

Q3

0.7 (0.5, 1.2) 0.246

0.7 (0.5, 1.2) 0.246

0.8 (0.4, 1.3) 0.282

Q4

0.7 (0.5, 1.2) 0.171

0.6 (0.4, 1.0) 0.055

0.7 (0.4, 1.1) 0.147

SHR group

   

Q1

Ref

Ref

Ref

Q2

1.1 (0.5, 1.5) 0.573

1.1 (0.5, 1.6) 0.648

1.2 (0.5, 1.6) 0.727

Q3

1.3 (0.5, 1.6) 0.487

1.3 (0.5, 1.6) 0.640

1.3 (0.5, 1.6) 0.712

Q4

1.5 (0.9, 2.4) 0.116

1.5 (0.9, 2.4) 0.090

1.4 (0.8, 2.4) 0.193

GV group

   

Q1

Ref

Ref

Ref

Q2

2.3 (1.2, 4.5) 0.010

2.3 (1.2, 4.5) 0.012

2.4 (1.2, 4.8) 0.010

Q3

2.2 (1.2, 4.2) 0.015

2.3 (1.2, 4.4) 0.012

2.5 (1.3, 4.8) 0.008

Q4

2.4 (1.3, 4.5) 0.005

2.4 (1.2, 4.5) 0.009

2.4 (1.2, 4.7) 0.010

28-day mortality

   

HbA1c group

   

Q1

Ref

Ref

Ref

Q2

0.9 (0.6, 1.4) 0.710

0.9 (0.6, 1.3) 0.516

1.0 (0.7, 1.5) 0.940

Q3

0.8 (0.6, 1.3) 0.410

0.8 (0.5, 1.2) 0.278

0.9 (0.6, 1.3) 0.521

Q4

1.0 (0.7, 1.4) 0.819

1.0 (0.6, 1.5) 0.830

1.0 (0.6, 1.6) 0.962

HGI group

   

Q1

Ref

Ref

Ref

Q2

0.5 (0.4, 0.8) 0.001

0.5 (0.3, 0.7) < 0.001

0.5 (0.3, 0.8) 0.001

Q3

0.8 (0.5, 1.1) 0.145

0.8 (0.5, 1.1) 0.176

0.9 (0.6, 1.4) 0.749

Q4

0.6 (0.4, 0.9) 0.022

0.6 (0.4, 0.9) 0.025

0.8 (0.5, 1.1) 0.160

SHR group

   

Q1

Ref

Ref

Ref

Q2

0.9 (0.6, 1.4) 0.695

0.9 (0.6, 1.3) 0.500

0.9 (0.6, 1.4) 0.580

Q3

1.2 (0.8, 1.8) 0.423

1.2 (0.8, 1.7) 0.499

1.1 (0.7, 1.6) 0.734

Q4

1.9 (1.3, 2.7) < 0.001

1.8 (1.2, 2.6) 0.003

1.6 (1.1, 2.4) 0.022

GV group

   

Q1

Ref

Ref

Ref

Q2

2.0 (1.3, 3.1) 0.003

1.9 (1.2, 3.0) 0.005

1.9 (1.2, 3.0) 0.006

Q3

2.1 (1.3, 3.3) 0.001

2.1 (1.3, 3.3) 0.001

2.1 (1.3, 3.3) 0.002

Q4

2.6 (1.7, 4.0) < 0.001

2.6 (1.7, 4.1) < 0.001

2.6 (1.6, 4.1) < 0.001

  1. with the outcome and p-value less than 0.05.
  2. Model 1: no covariates were adjusted.
  3. Model 2: adjusted for age, gender (male, female), body mass index (BMI), Hypertension (yes, no), Diabetes (yes, no), Heart Failure (yes, no), Chronic Kidney Disease (yes, no), acute kidney injury (yes, no), Hyperlipidemia (yes, no).
  4. Model 3: adjusted for Model 2 plus Laboratory indicators.
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