Fig. 3 | Scientific Reports

Fig. 3

From: Molecular dynamics simulations based siRNA design against GPR10 reveals stable RNAi therapeutics for hormone-dependent uterine fibroids

Fig. 3

Predicted secondary structures of selected siRNA candidates using MaxExpect. Secondary structures of siRNA3, siRNA6, siRNA8, siRNA10, siRNA12, siRNA13, siRNA14, siRNA17, siRNA18, and siRNA23 were generated based on minimum free energy predictions. Each structure is annotated with its corresponding free energy value (in kcal/mol), highlighting the conformational diversity and thermodynamic stability among siRNA designs. Lower energy values correspond to more thermodynamically stable conformations.

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