Fig. 4 | Scientific Reports

Fig. 4

From: Molecular dynamics simulations based siRNA design against GPR10 reveals stable RNAi therapeutics for hormone-dependent uterine fibroids

Fig. 4

Predicted secondary structures and free energies of siRNA duplexes targeting GPR10 mRNA. Ten siRNA candidates were evaluated for thermodynamic stability using RNAstructure’s DuplexFold algorithm. The secondary structures shown correspond to siRNA3, siRNA6, siRNA8, siRNA10, siRNA12, siRNA13, siRNA14, siRNA17, siRNA18, and siRNA23. Calculated minimum free energy (ΔG) values range from − 38.7 kcal/mol (siRNA6) to −31.4 kcal/mol (siRNA23), with more negative values indicating greater duplex stability.

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