Table 3 VaxiJen antigenicity score of the wild-type (WT) and modified (M) epitopic regions.

From: Epitope mapping strategies for immunogenicity mitigation in streptokinase therapeutics: an in-silico study

Epitope

N/M

Vaxijen

TSRPAHGGKTEQGLSPKSKPFATDSGAMSHKLEKAD (43–78)

N

0.9855

TSRPAHGGKTMQGLSPKSKPFATDSGAMSHKLEKAD

M

0.8089

DDDFRPGLKDTKLLKTLAIGDTITSQE (172–198)

N

0.5719

MDDFRPGLKDTKLLKTLAIGDTITSQE

M

0.5301

DDMFRPGLKDTKLLKTLAIGDTITSQE

M

0.3858

MDMFRPGLKDTKLLKTLAIGDTITSQE

M

0.4666

KNREQAYRINKKSGLNEEINNTDLI (246–270)

N

0.6728

KNREQAYRINKKWGLNEEINNTDLI

M

0.5738

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