Table 5 IEDB propensity scales of the residues 53, 174, and 258, before and after the alteration. As seen in the table, the scores are reduced in the Mutein residues (M) in comparison to the wildtype (WT).

From: Epitope mapping strategies for immunogenicity mitigation in streptokinase therapeutics: an in-silico study

 

Surface

Accessibility

Flexibility

Hydrophilicity

Res.

N

M

N

M

N

M

53

1.12

0.65

1.09

1.02

3.84

2.1

174

1.94

1.17

1.03

0.98

4.68

2.14

258

1.11

0.89

1.07

0.99

4.05

1.7

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