Table 2 Youden-optimal cut-offs for plasma biomarkers with sensitivity and specificity.

From: Stepwise approach to alzheimer’s disease diagnosis in primary care using cognitive screening, risk factors, neuroimaging and plasma biomarkers

 

CSF A + T+

CSF A+

Cut-off

Sensitivity

Specificity

AUC

Cut-off

Sensitivity

Specificity

AUC

p-tau181 (pg/mL)

≥ 24.76

0.62

0.81

0.710

≥ 22.78

0.66

0.80

0.755

GFAP (pg/mL)

≥ 115.98

0.92

0.70

0.852

≥ 115.98

0.80

0.77

0.813

NfL (pg/mL)

≥ 20.37

0.54

0.76

0.630

≥ 21.76

0.46

0.86

0.663

Aβ42/40 ratio

≤ 0.0544

0.77

0.56

0.690

≤ 0.0558

0.80

0.57

0.737

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