Fig. 2 | Scientific Reports

Fig. 2

From: Peroxiredoxins as novel indicators in multiple myeloma associated with ferroptosis and immune infiltration

Fig. 2

Expression, prognostic and diagnostic value of PRDXs in multiple myeloma. Transcriptional levels of (A) PRDX1 and (B) PRDX2 in various tumor cell lines as obtained from the CCLE database, with the solid line in the box representing the average levels. (C) PRDXs in HD and NDMM. (D) PRDXs in CD138 + MM cells (n = 126) and CD138-CD19 + B cells (n = 17) from myeloma patients. (E) PRDXs in HD (n = 15), MGUS (n = 22), SMM (n = 24), and MM (n = 73) patients. (F) PRDXs in baseline MM cells (n = 780) and relapsed MM cells (n = 258). (G) ROC curve of the diagnostic value of the PRDX family in MM, in which the x-axis is 1-specificity and the y-axis is sensitivity. The AUCs were recorded in the right corner. (H) Kaplan–Meier plotter analysis of the relationship between PRDX1 and OS, EFS, and PPS. (I) Kaplan–Meier analysis of the impact of PRDX2 expression on EFS. *P < 0.05, **P < 0.01, ***P < 0.001.

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