Fig. 5 | Scientific Reports

Fig. 5

From: Peroxiredoxins as novel indicators in multiple myeloma associated with ferroptosis and immune infiltration

Fig. 5

Role of PRDX2 in ferroptosis and immune infiltration. Percentage of CD45 + , CD3 + , and CD4 + /CD8 + T cells in high (A) and low (B) PRDX2 expression groups as detected by flow cytometry. (C) The expression of PRDX2 was negatively correlated with the proportion of CD4 + T cells, CD4 + T/CD8 + T cells, and the expression of IFN-γ, and positively correlated with the IL-6 and IL-8. (D–F) PRDX2 regulates ROS levels in RPMI-8226 and AMO1 cells (20x). (G–I) GSH, MDA, and ferrous ion were measured in RPMI-8226 and AMO1 cells. (J, K) Expression of GPX4 and SLC7A11 in MM patients and normal samples. (L) Expression levels and quantitative analyses of GPX4 and SLC7A11 in RPMI-8226 and AMO1 cells of the shNC and shPRDX2 groups. Data shown represent mean ± SD (N = 3). Full-length blots are presented in Supplementary Fig. 5.

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