Fig. 6 | Scientific Reports

Fig. 6

From: Peroxiredoxins as novel indicators in multiple myeloma associated with ferroptosis and immune infiltration

Fig. 6

PRDX2 enhanced the resistance to ferroptosis in MM cells. (A) Dose–response curves of the RSL3 in RPMI-8226 and AMO1 cells transfected with either shNC or shPRDX2. MM cells in the two transfection groups were further divided into four treatment groups: vehicle control, Fer-1 treatment alone, RSL3 treatment alone and combination treatment with both RSL3 and Fer-1. Cell proliferation (B), invasion (C), migration (D), and ferroptosis phenotypes (E–H) were assessed across these groups. (I) Key ferroptosis-related signaling proteins were also assessed for the above groups. Data shown represent mean ± SD (N = 3). Full-length blots are presented in Supplementary Fig. 6.

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