Fig. 4
From: Systematic metabolomic study on the plasma and urine of a mouse model of Alport syndrome
Multivariate and pathway analysis of urinary metabolites in WT and AS mice at 4 weeks (A–C) and 7 weeks (D–F) by using 42 selected discriminatory metabolites. (A,D) PLS-DA score plots showing the separation between the WT and AS groups. (B,E) VIP scores from PLS-DA analysis, highlighting the top metabolites contributing to group separation. (C,F) Metabolic pathway enrichment plots based on the identified discriminatory metabolites. Circle size reflects pathway impact; color intensity reflects − log10 (p value), where red corresponds to more significant pathways.
