Fig. 4

Contribution of JNK to the induction or the enlargement of intracranial aneurysm lesions in mice. Suppressive effect of the genetic deletion of Jnk1 and Jnk2 on the incidence of intracranial aneurysm (IA) lesions or the size of induced lesions in mice. Wild type mice, ones deficient in Jnk1 or Jnk2 was subjected to IA induction and the incidence of IAs or the size of induced lesions was histopathologically assessed after Elastica van Gieson staining. Number of animals used is shown in the parenthesis. Statistical analyses was done by using the Fisher’s Exact test in (A) or the Kruskal–Wallis Test in (B). *p < 0.05. The representative images of histopathological analyses are shown in (C). Arrow heads in (C) indicate the border of IA lesion. Scale bar: 50 μm. Systolic blood pressure was measured by tail-cuff method before sacrifice and its value is shown in (D). Bars indicate mean + /– s.e.m.