Fig. 3 | Scientific Reports

Fig. 3

From: Diesel particulate matter-induced proteomic changes in three-dimensional spheroids derived from human primary cells of various tissue origins

Fig. 3

Interaction of 41 proteins that showed significant changes (> 1.5 or < 0.67) in the spheroids exposed to the highest DPM concentrations compared to unexposed spheroids at 48 h across all eight spheroid types, with statistical significance (P-value < 0.05) related to DPM concentrations as determined by two-way ANOVA analysis. Of these, 38 proteins that were connected in the network are visualized. The analysis was done using protein interaction information from the STRING database and visualized using Cytoscape. Each node represents a protein that is colored on the log2 fold change values in the spheroids exposed to the highest DPM concentrations compared to unexposed spheroids at 48 h based on NEC-S dataset, with red representing upregulated proteins and blue indicating downregulated proteins. Additionally, the edges of the nodes are represented in a donut shape, with the color of the edges depicting the corresponding GO BP terms.

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