Table 1 Summary of two-way ANOVA results and the number of proteins showing statistically significant changes in response to DPM exposure in eight spheroid types.

From: Diesel particulate matter-induced proteomic changes in three-dimensional spheroids derived from human primary cells of various tissue origins

Spheroids

Number of proteins with quantifiable information

P-value_

time pointsa <0.05

P-value_DPM concentrationsb

< 0.05

P-value_

interactionc

< 0.05

NEC-S

6,194

3,107

646

215

B/TEC-S

6,214

839

3,049

435

LF-S

5,780

1,445

2,662

507

SAEC-S

6,748

920

1,751

307

M-S

6,888

891

2,311

259

A-S

6,391

251

3,143

153

DF-S

5,113

1,138

2,651

911

CAEC-S

5,148

2,339

2,199

524

  1. *NEC-S, B/TEC-S, LF-S, SAEC-S, M-S, A-S, DF-S, and CAEC-S represent nasal epithelial cell-derived spheroids, bronchial/tracheal epithelial cell-derived spheroids, lung fibroblast-derived spheroids, small airway epithelial cell-derived spheroids, microglia-derived spheroids, astrocyte-derived spheroids, dermal fibroblast-derived spheroids, and coronary artery endothelial cell-derived spheroids, respectively.
  2. aP-value was obtained from two-way ANOVA comparison of the log2(normalized signal-to-noise values) and indicates the statistical significance between 24 and 48 h.
  3. bP-value was derived from two way ANOVA comparison of the log2(normalized signal-to-noise values) and reflects the statistical significance among different diesel particulate matter (DPM) concentrations.
  4. cP-value was obtained from two way ANOVA comparison of the log2(normalized signal-to-noise values) and indicates the statistical significance interaction between time points and DPM concentrations.
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