Table 4 Expression level of p53, Bax and Bcl2 genes in the untreated control and treated hepatic cancer Hep-G2 cells with doxorubicin and frankincense nano-emulsion.

From: Frankincense oil nanoemulsion induces selective cytotoxicity and over ROS-mediated oxidative stress and apoptotic DNA damage in Hep-G2 hepatic cancer cells

Treatment

Concentration

p53 gene

Bax gene

Bcl2 gene

Untreated cells

0.00

1.00 ± 0.00 a

1.00 ± 0.00 a

1.00 ± 0.00 a

Doxorubicin

2 µM

2.43 ± 0.13 b

1.84 ± 0.10 b

0.95 ± 0.06 a

Frankincense nano-emulsion

44.03 µg/ml

1.87 ± 0.11 c

1.66 ± 0.07 b

0.82 ± 0.05 b

88.07 µg/ml

2.62 ± 0.20 c

2.39 ± 0.06 c

0.65 ± 0.04 c

176.14 µg/ml

3.49 ± 0.19 d

3.16 ± 0.21 d

0.49 ± 0.06 d

ANOVA

F = 117.03 p < 0.001

F = 161.48 p < 0.001

F = 52.65 p < 0.001

  1. Results are expressed as mean ± SD.
  2. Results were analyzed using one-way analysis of variance followed by Duncan’s test to test the similarity between the control and treated Hep-G2 cancer cells.
  3. Means with different letters indicates statistical significant difference at p < 0.001 between the compared cells in the same column.
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