Fig. 8 | Scientific Reports

Fig. 8

From: Extracellular vesicle-associated transcriptomic and proteomic biomarkers show in vitro potential for vandetanib treatment monitoring in anaplastic thyroid cancer

Fig. 8

Biological relevance and discriminatory power of the biomarker candidates. (a) Pathway ORA of the 21 biomarker candidates in the total RNA-Seq dataset, filtered by padj < 0.1 and sorted by fold enrichment. Pathway names are indicated on the y-axis, and colors represent the corresponding database. The names of the biomarker candidate genes contributing to each pathway are indicated next to the bars. (b) Two-dimensional projection of the samples in the first two dimensions of a partial least-squares regression of the delta Cq values measured in the cfRNA. Black squares, yellow dots, orange triangles and red diamonds indicate the DMSO control, EC10, EC50 and EC80 dose, respectively. Ellipses represent 95% CIs. (c) Receiver operating characteristic (ROC) curves and area under the curve (AUC) values for the PLS regression model of the eight biomarker candidates’ delta Cq values.

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