Table 7 Predicted IC50 values of compounds of E. prostrata against targets FLT3 and PIM1.

From: In silico approaches unveil the mechanism of action of Eclipta prostrata against acute myeloid leukemia

Targets

FLT3

PIM1

Compounds (PubChem CID)

Predicted activity (pIC50)

Predicted

IC50 (nM)

Predicted activity (pIC50)

Predicted IC50 (nM)

Acacetin (5280442)

-2.711

514.04

-2.844

698.23

Apigenin (5280443)

-2.77

588.84

-2.825

668.34

Coniferaldehyde (5280536)

-2.487

306.90

-2.151

141.58

Coumestan (638309)

-2.469

294.44

-2.264

183.65

Diosmetin (5281612)

-2.682

480.84

-2.719

523.60

Kaempferide (5281666)

-2.604

401.79

-3.078

1196.74

Kaempferol (5280863)

-2.693

493.17

-3.054

1132.40

Skullcapflavone II (124211)

-2.421

263.63

-2.658

454.99

Syringic acid (10742)

-2.463

290.40

-1.766

58.34

Tricetin (5281701)

-2.769

587.49

-2.609

406.44

Vanillic Acid (8468)

-2.652

448.75

-1.974

94.19

Pacritinib (Control) (46216796)

-2.934

859.01

  

SEL24 (Control) (76286825)

  

-3.049

1119.44

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