Fig. 2

(A) Transmission electron micrograph of EVs. (B–D) EV miRNA analysis. Log fold change expression of miRNA in aged vs. young sera (B) miR-23-27-24 cluster, (C) miR-17-92 cluster and (D) miR-146a/155 axis. (E,F) Pathway enrichment analysis of miRNA in aged vs. young sera. (E) most significant enriched pathways relevant to adipose tissue and immunosignaling, (F) Log fold change expression of miRNA involved in adipokine signaling.