Fig. 1

Long-term HFD feeding induces obesity in C57BL/6 mice. (A) Changes in body weight of mice fed a low-fat diet (LFD) or high-fat diet (HFD) for 10 Weeks. *P < 0.05, **P < 0.01, ***P < 0.001 versus LFD; n = 5 each group. (B) Triglyceride content in the plasma of LFD-fed or HFD-fed mice. ***P < 0.001 versus LFD; n = 5 each group. (C) Cholesterol content in the plasma of LFD-fed or HFD-fed mice. ***P < 0.001 versus LFD; n = 5 each group. (D) Free fatty acid (FFA) content in the plasma of LFD-fed or HFD-fed mice. ***P < 0.001 versus LFD; n = 5 each group. (E) TNF-a content in the plasma of LFD-fed or HFD-fed mice. **P < 0.01 versus LFD; n = 5 each group. (F) Triglyceride content in colonic mucosa of LFD-fed or HFD-fed mice. **P < 0.01 versus LFD; n = 5 each group.