Fig. 5 | Scientific Reports

Fig. 5

From: Obesity exacerbates experimental colitis due to the activation of the local renin–angiotensin system in the colon

Fig. 5

Blockade of AT1 receptor signaling ameliorates intestinal permeability and Th17 cells expression under long-term HFD. (A) Quantitation of paracellular FITC-dextran passage across mucosal barrier in mice. **P < 0.01, ***P < 0.001 versus respective HFD or HFD LST; ##P < 0.01, versus HFD TNBS; n = 5 each group. (B) Western blot analyses of occludin in colonic mucosal lysates. (C) Densitometric quantitation of occludin in colonic mucosal lysates. **P < 0.01 versus respective HFD or HFD LST; ##P < 0.01 versus HFD or HFD TNBS; n = 3 each group. Only representative blots are shown. (D) Representative FACS plots for Th17 cells in the colonic lamina propria. (E) Quantitation of Th17 cells. **P < 0.01 versus respective HFD or HFD LST; ##P < 0.01 versus HFD or HFD TNBS. n = 5 per group.

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