Table 6 MANOVA and ANOVA for longitudinal assessment in patients, stratified by outcome.

From: Diffusion-weighted imaging and retinal oximetry as potential biomarkers of visual outcomes after optic neuritis

MANOVA

ANOVA

Model

Factor

Wilk’s λ

df*

F

p

Partial η2

Variable

df*

F

p†

Partial η2

Stratified by outcome

Abnormal outcome

0.304

4, 12

6.883

0.004

0.696

FA

1, 15

8.058

0.012

0.349

MD

1, 15

0.424

0.525

0.027

AD

1, 15

3.037

0.102

0.168

f2

1, 15

1.566

0.230

0.095

Time

0.641

8, 8

0.560

0.785

0.359

     

Hemisphere

0.263

4, 12

8.396

0.002

0.737

FA

1, 15

3.911

0.067

0.207

MD

1, 15

11.436

0.004

0.433

AD

1, 15

28.808

 < 0.001

0.658

f2

1, 15

27.090

 < 0.001

0.644

Abnormal outcome × time

0.636

8, 8

0.571

0.777

0.364

     

Abnormal outcome × hemisphere

0.856

4, 12

0.503

0.734

0.144

     

Time × hemisphere

0.153

8, 8

5.529

0.013

0.847

FA

2, 30

1.763

0.189

0.105

MD

2, 30

1.041

0.365

0.065

AD

2, 30

1.270

0.295

0.078

f2

2, 30

0.855

0.435

0.054

Abnormal outcome × time × hemisphere

0.253

8, 8

2.947

0.074

0.747

     
  1. *Order: hypothesis df, error df; †Bonferroni-corrected significance level p < 0.0125 for n = 4 marked in bold.
  2. AD axial diffusivity, ANOVA analysis of variance, df degrees of freedom, f2 secondary partial volume fraction, FA fractional anisotropy, MANOVA multivariate ANOVA, MD mean diffusivity.
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