Fig. 3
Kaplan–Meier survival curves for PFS and OS in all patients based on TROP2 intensity [PFS (A), OS (B)] and proportion [PFS (C), OS (D)]. Subgroup analyses by PD-L1 expression (PD-L1 < 1%: PFS (E), OS (F); PD-L1 ≥ 1%: PFS (G), OS (H)) and histology (AD: PFS (I), OS (J); non-AD: PFS (K), OS (L)) for TROP2 intensity. Those of PD-L1 expression (PD-L1 < 1%: PFS (M), OS (N); PD-L1 ≥ 1%: PFS (O), OS (P)) and histology (AD: PFS (Q), OS (R); non-AD: PFS (S), OS (T)) for TROP2 proportion. AD, adenocarcinoma. Median PFS and OS values, hazard ratios (HR) with 95% confidence intervals (CI), and log-rank p-values were as follows: all patients (Intensity): median PFS 298 vs 151 days (HR = 1.26, 95% CI 1.01–1.59, p = 0.041) [A]; median OS NR vs 356 days (HR = 1.52, 95% CI 1.14–2.02, p = 0.003) [B]. all patients (Proportion): median PFS 285 vs 189 days (HR = 1.19, 95% CI 0.94–1.49, p = 0.138) [C]; median OS 784 vs 443 days (HR = 1.22, 95% CI 0.93–1.60, p = 0.150) [D]. PD-L1 < 1% (Intensity): PFS 336 vs 139 days (HR = 1.25, 95% CI 0.88–1.76, p = 0.207) [E]; OS 784 vs 372 days (HR = 1.50, 95% CI 0.99–2.28, p = 0.048) [F]. PD-L1 ≥ 1% (Intensity): PFS 276 vs 151 days (HR = 1.38, 95% CI 1.01–1.88, p = 0.038) [G]; OS NR vs 353 days (HR = 1.65, 95% CI 1.10–2.49, p = 0.012) [H]. AD (Intensity): PFS 336 vs 178 days (HR = 1.24, 95% CI 0.91–1.71, p = 0.169) [I]; OS NR vs 365 days (HR = 1.60, 95% CI 1.08–2.37, p = 0.016) [J]. non-AD (Intensity): PFS 255 vs 139 days (HR = 1.23, 95% CI 0.88–1.72, p = 0.211) [K]; OS 784 vs 353 days (HR = 1.40, 95% CI 0.93–2.11, p = 0.099) [L]. PD-L1 < 1% (Proportion): PFS 325 vs 139 days (HR = 1.21, 95% CI 0.86–1.70, p = 0.266) [M]; OS 714 vs 383 days (HR = 1.30, 95% CI 0.88–1.93, p = 0.179) [N]. PD-L1 ≥ 1% (Proportion): PFS 270 vs 189 days (HR = 1.28, 95% CI 0.92–1.77, p = 0.139) [O]; OS NR vs 545 days (HR = 1.27, 95% CI 0.86–1.88, p = 0.232) [P]. AD (Proportion): PFS 298 vs 228 days (HR = 1.03, 95% CI 0.75–1.42, p = 0.855) [Q]; OS NR vs 591 days (HR = 1.16, 95% CI 0.78–1.71, p = 0.470) [R]. non-AD (Proportion): PFS 285 vs 134 days (HR = 1.39, 95% CI 1.00–1.93, p = 0.046) [S]; OS 714 vs 291 days (HR = 1.34, 95% CI 0.91–1.97, p = 0.134) [T].
