Fig. 10
Representative histopathological features of lung grafts at different time points following transplantation and in the Sham control group. Each column corresponds to a post-transplantation time point (Sham, Month 2, Month 4, and Month 6), while each row depicts a distinct histological evaluation: low magnification H&E staining, high magnification H&E staining, perivascular region (H&E), and Masson’s trichrome staining. (A) Sham control: H&E-stained section showing preserved alveolar architecture with no evidence of congestion, inflammatory infiltrates, or atelectasis. (B–D) Low magnification H&E-stained sections from Month 2, 4, and 6, respectively, illustrating decreasing peribronchial inflammation and alveolar congestion over time. (E–G) High magnification H&E-stained views highlighting marked alveolar macrophage accumulation at Month 2 (E), minimal peribronchial infiltrates at Month 4 (F), and residual inflammation at Month 6 (G). (H–J) Perivascular H&E-stained sections demonstrating mild lymphoplasmacytic inflammation at Months 2, 4, and 6. (K) Sham control: Masson’s trichrome-stained section showing no collagen deposition or fibrosis. (L–N) Trichrome-stained sections from Month 2, 4, and 6, respectively, revealing gradual peribronchial and interalveolar collagen deposition consistent with evolving chronic fibrotic remodeling.
