Fig. 3

Analysis of global miRNA expression patterns represented as: (a) heatmap of expression levels generated by unsupervised hierarchical clustering and (b) volcano plot showing differences between PGC and SC samples. The pie chart inside volcano plot shows the percentage of upregulated and downregulated miRNAs. The 5 miRNAs (miR-451, miR-484, miR-871-3p, miR-107-3p, and let-7c-3p) validated by RT-qPCR are highlighted.