Fig. 2
From: Aging alters genomic instability at endogenous mutation hotspots in mice
Aging alters H-DNA-induced genetic instability in a tissue-specific manner. Mutation frequencies in young (2-month) versus aged (18-month) female mice from (A) spleen, (A) liver, and (A) brain per 10,000 colonies. Frequencies were calculated from genome-integrated mutation reporters containing either a B-DNA sequence or H-DNA-forming sequence from the human c-MYC gene. Data points are presented on violin plots with the median and quartiles, n > 3 mice, statistical significance determined using one-way ANOVA followed by Sidak’s multiple comparisons *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
