Fig. 5
From: Aging alters genomic instability at endogenous mutation hotspots in mice
NER is delayed in aging tissues. (A) Experimental schematic of NER UV lesion removal assay. (B) UV lesions detected over a time-course from young and aged brain WCE. (C) 6 − 4 Photoproduct immunoslot blot (top) and SYBR Gold-stained DNA blot (bottom) from NER assay in brain WCE. (D) UV lesions detected over a time-course from young and aged spleen WCE. (E) 6 − 4 Photoproduct immunoslot blot (top) and SYBR Gold-stained DNA blot (bottom) from NER assay in spleen WCE. Error bars represent mean ± SEM, n = 3 mice, statistical significance determined using student’s t-test. *p < 0.05.
