Table 3 Intra- and inter-grader agreement analysis on UCI cystinosis corneal crystal scoring (CCCS) system. The table presents kappa (κ) values, p-values, intraclass correlation coefficient (ICC) with 95% confidence intervals, and standard errors for intra-rater and inter-rater reliability. The UCI CCCS system demonstrated excellent reliability, with κ values of 0.922 for intra-rater and 0.869 for inter-rater reliability, with p-values < 0.001 and standard errors below 5%.

From: Introducing the University of California, Irvine Corneal Cystine Crystal Score: A Novel Tool for Assessing Corneal Crystal Deposition in Cystinosis Patients

 

Kappa

P value

ICC (95% interval)

Standard Error (%)

Intra-rater Reliability

0.922

< 0.001

0.883–0.962

< 5%

Inter-rater Reliability

0.869

< 0.001

0.830–0.909

< 5%

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