Table 4 COX-1/-2 inhibitory properties of the tested agents at 10 μM.
Compd | % Inhibition of COX-1 ± SEM | % Inhibition of COX-2 ± SEM | SI |
|---|---|---|---|
17a | 49.8 ± 1.8 | 64.9 ± 2.8 | 0.96 |
17b | 53.7 ± 3.7 | 61.3 ± 2.6 | 1.04 |
17c | 58.6 ± 3.5 | 53.9 ± 1.7 | 1.05 |
17d | 51.8 ± 2.2 | 56.4 ± 1.9 | 0.82 |
17e | 55.0 ± 3.6 | 59.6 ± 1.3 | 1.08 |
17f | 57.6 ± 1.1 | 60.8 ± 2.7 | 1.01 |
17g | 62.1 ± 3.1 | 51.8 ± 2.8 | 0.96 |
17h | 53.5 ± 2.8 | 51.5 ± 3.1 | 1.06 |
17i | 46.2 ± 2.4 | 49.7 ± 1.9 | 1.09 |
17j | 48.9 ± 1.5 | 53.5 ± 2.3 | 1.05 |
17k | 57.7 ± 1.0 | 55.0 ± 1.6 | 1.30 |
17l | 61.6 ± 1.2 | 50.3 ± 2.3 | 0.92 |
17m | 58.3 ± 3.0 | 60.9 ± 1.1 | 0.93 |
17n | 50.6 ± 2.3 | 47.3 ± 1.4 | 1.08 |
17o | 61.7 ± 3.4 | 59.3 ± 2.4 | 1.14 |
17p | 51.1 ± 2.7 | 53.5 ± 2.1 | 1.10 |
17q | 61.3 ± 1.5 | 62.1 ± 3.1 | 0.93 |
17r | 55.5 ± 2.6 | 51.8 ± 2.0 | 1.09 |
17s | 53.8 ± 2.8 | 56.3 ± 2.3 | 0.83 |
17t | 49.2 ± 1.9 | 63.7 ± 1.7 | 1.29 |
Ibuprofen | 65.3 ± 1.2 | 71.3 ± 1.8 | 0.95 |
Indomethacin | 64.3 ± 2.7 | 68.3 ± 1.6 | 1.09 |
