Table 2 Direct comparison of epirubicin and internal standard signal responses at baseline (T0) using traditional vs. True Dose methods.

From: Development and evaluation of a novel capillary blood collection method for decentralized therapeutic drug monitoring using the True Dose kit

Storage duration

Method

No. of samples (n)

Epi (AUC)

Dox (AUC)

Ratio epi/doxo (A.U.)

Daunorubicin (AUC)

Ratio epi/dauno (A.U.)

S/N (Epi)

% Agreement (Traditional/True Dose)

 

T0

Traditional

35

48,312

10,639

4.63

NA

NA

3,240

  

T0

True Dose

34

47,118

9,712

4.86

19,394

2,59

3,900

95.3

 
  1. AUC = area under the concentration-time curve; S/N = signal-to-noise ratio; epi/doxo = ratio of epirubicin to doxorubicin; epi/dauno = ratio of epirubicin to daunorubicin; NA = not applicable. All ratios are reported in arbitrary units (A.U.). % Agreement = (Traditional epi/doxo ÷ True Dose epi/doxo) × 100.
Back to article page