Table 3 Stability of epirubicin and internal standards in True Dose samples stored at room Temperature. Analysis of signal integrity and internal standard ratios at 18 h, 3 days, 7 days, and 14 days post-sampling using the True Dose kit.

From: Development and evaluation of a novel capillary blood collection method for decentralized therapeutic drug monitoring using the True Dose kit

Storage duration

Method

No. of samples (n)

Epirubicin (AUC)

Doxorubicin (AUC)

Ratio epi/doxo (A.U.)

Daunorubicin (AUC)

Ratio epi/dauno (A.U.)

S/N (Epi)

% Agreement (Traditional/True Dose)

18 h

True Dose

15

49,484

11,283

4.39

22,495

2.20

2,500

105.4

3 days

True Dose

15

51,612

12,496

4.13

26,113

1.98

4,400

112.1

7 days

True Dose

15

52,488

12,132

4.33

25,214

2.08

3,600

107.0

14 days

True Dose

15

42,101

9,316

4.52

21,398

1.97

4,200

102.4

  1. AUC = area under the concentration–time curve; S/N = signal-to-noise ratio; epi/doxo = ratio of epirubicin to doxorubicin; epi/dauno = ratio of epirubicin to daunorubicin. All ratios are reported in arbitrary units (A.U.). % Agreement = (Traditional epi/doxo ÷ True Dose epi/doxo) × 100.
Back to article page