Table 2 Determinants of very high erythropoietin levels.
Characteristic | Number (%) with very high EPO level | Unadjusted odds ratio (OR), 95%CI, and p-value | Adjusted odds ratio (AOR), 95%CI, and p-value |
|---|---|---|---|
Gender | |||
Male (n = 22) | 16 (72.7%) | OR = 3.48 95%CI = 1.07–11.3 p = 0.035 | AOR = 6.911 95%CI = 0.90–52.7 p = 0.062 |
Female (n = 30) | 13 (43.3%) | ||
Age category | |||
Children (n = 17) | 14 (82.4%) | OR = 6.22 95%CI = 1.51–25.6 p = 0.007 | AOR = 0.75 95%CI = 0.03–20.0 p = 0.868 |
Adults (n = 35) | 15 (42.9%) | ||
Age at diagnosis | |||
= < 4 years (n = 31) | 21 (67.7%) | OR = 3.41 95%CI = 1.07–10.8 p = 0.035 | AOR = 5.10 95%CI = 0.77–33.6 p = 0.090 |
> 4 years (n = 21) | 8 (38.1%) | ||
No. of transfusions | |||
< 100 (n = 15) | 11 (73.3%) | OR = 2.90 95%CI = 0.78–10.7 p = 0.104 | AOR = 1.22 95%CI = 0.03–42.0 p = 0.909 |
> 100 (n = 37) | 18 (48.6%) | ||
Transfusion dependency | |||
Transfusion dependent (n = 32) | 17 (53.1%) | OR = 0.75 95%CI = 0.24–2.34 p = 0.627 | AOR = 7.41 95%CI = 0.29–185.6 p = 0.223 |
Non-transfusion dependent (n = 20) | 12 (60.0%) | ||
Pre-transfusion haemoglobin | |||
< 7 g/dL (n = 29) | 18 (62.1%) | OR = 1.78 95%CI = 0.58–5.41 p = 0.304 | AOR = 4.00 95%CI = 0.72–22.0 p = 0.111 |
> = 7 g/dL (n = 23) | 11 (47.8%) | ||
Splenectomy | |||
Non-splenectomy (n = 36) | 25 (69.4%) | OR = 6.81 95%CI = 1.79–25.9 p = 0.003 | AOR = 15.9 95%CI = 1.80–140.9 p = 0.013 |
Splenectomised (n = 16) | 4 (25.0%) | ||
Hydroxyurea treatment | |||
On hydroxyurea (n = 13) | 10 (76.9%) | OR = 3.50 95%CI 0.83–14.73 p = 0.076 | AOR = 6.35 95%CI = 0.73–54.9 p = 0.093 |
Not on hydroxyurea (n = 39) | 19 (48.7%) | ||
Ferritin | |||
< 1000 ng/mL (n = 20) | 14 (70.0%) | OR = 2.64 95%CI = 0.81–8.62 p = 0.102 | AOR = 4.61 95%CI = 0.42–50.3 p = 0.210 |
> = 1000 ng/mL (n = 32) | 15 (46.9%) | ||
