Fig. 1 | Scientific Reports

Fig. 1

From: Dual-targeting antioxidant and anti-glycation strategy inhibits melanogenesis through clinical and mechanistic study

Fig. 1

Effect of dual-effect composition (DEC) on UVB-induced oxidative stress and melanogenesis in A875 melanoma cells. (A) Cytotoxicity of DEC in A875 cells. (B, C) Nrf2 and HO-1 protein levels were measured by ELISA. (D, E) Fluorescence staining and quantification for reactive oxygen species (ROS). Scale bar = 50 μm. (F) Relative melanin contents in A875 cells. (G) qRT-PCR analysis of TYR mRNA expression levels. Data are expressed as the mean ± SD (n = 3). ##P < 0.01 vs. blank control (BC). **P < 0.01 vs. UVB. Positive control (PC) was treated with a combination of vitamin C and vitamin E.

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