Fig. 2 | Scientific Reports

Fig. 2

From: Dual-targeting antioxidant and anti-glycation strategy inhibits melanogenesis through clinical and mechanistic study

Fig. 2

Effect of dual-effect composition (DEC) on AGE-induced glycation damage and melanogenesis in A875 melanoma cells. (A, C) Immunofluorescence staining and quantification for RAGE. (B, D) Immunofluorescence staining and quantification for CML. Scale bar = 50 μm. (E) Relative melanin contents in A875 cells. (F) qRT-PCR analysis of TYR mRNA expression levels. Data are expressed as the mean ± SD (n = 3). ##P < 0.01 vs. blank control (BC). *P < 0.05 and **P < 0.01 vs. AGE-BSA. Positive control (PC) was treated with aminoguanidine hydrochloride.

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