Fig. 4 | Scientific Reports

Fig. 4

From: Dual-targeting antioxidant and anti-glycation strategy inhibits melanogenesis through clinical and mechanistic study

Fig. 4

Anti-glycation effects of dual-effect composition (DEC)-containing serum on a pigmented full-thickness human skin model exposed to methylglyoxal (MGO) and UV irradiation. (A, B) Immunofluorescence staining of N-carboxymethyllysine (CML) expression. Scale bar = 50 μm. (C) qRT-PCR analysis of RAGE mRNA expression levels. Data are expressed as the mean ± SD (n = 3). ##P < 0.01 vs. blank control (BC; untreated baseline). and **P < 0.01 vs. negative control (NC; MGO + UV irradiation). ^^P < 0.01; ns, not significant (P > 0.05). Positive control (PC) was treated with aminoguanidine sulfate.

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