Fig. 5 | Scientific Reports

Fig. 5

From: Dual-targeting antioxidant and anti-glycation strategy inhibits melanogenesis through clinical and mechanistic study

Fig. 5

Effect of dual-effect composition (DEC)-containing serum on melanogenesis in a pigmented full-thickness human skin model exposed to methylglyoxal (MGO) and UV irradiation. Immunofluorescence staining analysis of (A) MITF and (B) TYR expression. (C) Masson-Fontana staining for the qualitative assessment of melanin content. Scale bar = 50 μm. (D) Apparent chromaticity images of skin models. Data are expressed as the mean ± SD (n = 3). ##P < 0.01 vs. blank control (BC; untreated baseline). *P < 0.05 and **P < 0.01 vs. negative control (NC; MGO + UV irradiation). ^^P < 0.01; ns, not significant (P > 0.05). Positive control (PC) was treated with kojic acid.

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