Table 2 Prevalence of various risk factors and their association with long-term ventilation in the overall cohort, as well as separately for women and men.

From: Sex-specific differences in risk factors and outcomes for long-term mechanical ventilation: a longitudinal cohort analysis of claims data

Predictor

All

Female

Male

Difference

Prevalence [%]

OR (95% CI)

Prevalence [%]

OR (95% CI)

Prevalence [%]

OR (95% CI)

p-value

Baseline predictors

 Intercept

       

 Age [years]

 

1.00 (0.99–1.00)

-

0.99 (0.98–0.99)

-

1.00 (1.00–1.00)

 

 Sex [female]

 

0.91 (0.83–1.01)

-

-

-

-

 

 Nursing home accommodation

3.4

0.65 (0.49–0.87)

4.5

0.62 (0.91–2.16)

2.7

0.66 (0.46–0.94)

 < 0.001

Diagnosis

 Pre-existing medical conditions (in 365 days prior to the MV case)

  Dementia

7.7

1.87 (1.25–2.78)

8.2

1.40 (0.91–2.16)

7.3

2.68 (1.44–5.01)

0.2228

  Thyroiditis

1.2

0.88 (0.73–1.05)

2.3

1.05 (0.81–1.37)

0.4

0.84 (0.68–1.04)

 < 0.001

  Eating disorders

0.5

2.2 (1.2–4.03)

0.8

0.95 (0.46–1.98)

1.1

3.16 (1.37–7.26)

0.0015

  Rheumatic mitral valve disease

1.5

2.37 (1.68–3.33)

2.3

2.74 (1.82–4.12)

0.6

1.71 (1.08–2.72)

 < 0.001

  Pneumothorax

0.6

2.24 (1.19–4.22)

0.5

1.76 (0.73–4.25)

0.9

1.94 (1.02–3.69)

0.8761

Peritonitis

1.0

0.56 (0.32–0.96)

1.2

0.70 (0.36–1.36)

0.9

0.55 (0.3–1)

0.1601

Admission diagnosis

 Cardiac arrhythmia

0.9

0.66 (0.39–1.12)

0.6

0.75 (0.29–1.93)

1.2

0.89 (0.54–1.46)

0.0012

 Cerebral infarction

2.9

2.08 (1.58–2.73)

3.0

1.41 (0.97–2.07)

2.8

2.33 (1.72–3.14)

0.4503

 Acute pancreatitis

0.6

3.57 (2.02–6.3)

0.3

4.73 (1.62–13.78)

0.7

3.01 (1.69–5.37)

0.0166

Diseases (previous diseases, admission diagnosis, MV case)

 Pulmonary or abdominal metastasis

2.5

0.63 (0.45–0.88)

2.4

0.67 (0.41–1.09)

2.6

0.71 (0.5–1)

0.6658

 COPD

30.7

1.85 (1.68–2.05)

29.3

1.79 (1.54–2.08)

31.5

1.73 (1.55–1.93)

0.0118

 Dependence on aspirator and/or ventilator (Non-invasive ventilation)

5.0

6.1 (4.8–7.76)

4.6

5.56 (3.97–7.77)

5.2

6.19 (4.81–7.96)

0.2251

Operations and procedures

 Operations and procedures in the 365 days prior to the MV case

  Tracheostomy. permanent or temporary

3.3

2.53 (1.96–3.28)

3.2

3.23 (2.24–4.66)

3.3

2.73 (2.06–3.61)

0.8068

  Creation of a dialysis fistula. shunt or bypass

0.8

0.34 (0.17–0.65)

0.4

0.24 (0.05–1.13)

1.0

0.49 (0.27–0.9)

 < 0.001

 Operations and procedures during theMV case up to 95 h after intubation

  Bronchoscopy

35.1

1.15 (1.04–1.27)

33.4

1.20 (1.03–1.38)

36.1

1.15 (1.04–1.28)

0.0029

  Native computed tomography of the chest

13.2

1.16 (1.01–1.33)

12.5

1.16 (0.95–1.43)

13.7

1.04 (0.9–1.21)

0.0695

  Computed tomography and/or magnetic resonance imaging of the cranium with imaging contrast medium

10.7

1.34 (1.15–1.56)

10.8

1.22 (0.99–1.52)

10.7

1.31 (1.11–1.54)

0.832

  Operations on the spinal cerebrospinal fluid system (drainage. shunt. catheter; also. removal)

0.4

2.54 (1.33–4.86)

0.4

5.69 (1.92–16.83)

0.5

2.01 (0.97–4.18)

0.7901

  Tracheostomy, permanent or temporary

12.8

4.17 (3.63–4.78)

12.5

4.44 (3.63–5.41)

12.9

3.63 (3.12–4.22)

0.5367

  Radical cervical lymphadenectomy

0.7

0.25 (0.13–0.5)

0.6

0.09 (0.02–0.39)

0.8

0.26 (0.13–0.51)

0.4943

  Chest tube

10.8

1.35 (1.16–1.57)

11.0

1.27 (1.03–1.58)

10.6

1.23 (1.05–1.45)

0.5556

  Positioning treatment in a special bed**

2.4

2.37 (1.78–3.15)

2.2

2.07 (1.35–3.17)

2.4

2.27 (1.66–3.13)

0.5035

  Autologous blood collection and transfusion

2.7

0.71 (0.51–0.97)

2.1

0.6 (0.35–1.01)

3.0

0.83 (0.61–1.15)

0.0064

  Transfusion of plasma components and genetically engineered plasma proteins

13.0

1.46 (1.27–1.69)

12.4

1.4 (1.14–1.73)

13.4

1.43 (1.22–1.66)

0.1440

  PECLA. ECCO2R. vv- und va ECMO und Pre-ECMO therapy

3.4

1.43 (1.11–1.85)

2.6

0.93 (0.6–1.42)

3.9

1.62 (1.25–2.1)

 < 0.001

  Complex treatment for colonization or infection with multidrug-resistant pathogens

6.1

1.46 (1.2–1.78)

5.7

1.36 (1.03–1.81)

6.4

1.44 (1.17–1.77)

0.1166

  1. The prevalence (%) of risk factors is shown in the first column for the overall cohort. The second column presents the independent associations with the risk of long-term ventilation (OR (95% CI)) according to the criteria outlined in Table S1. The subsequent columns show the associations from models created separately for men and women. Abreviations: COPD: Chronic Obstructive Pulmonary Disease, PECLA: Pumpless Extracorporeal Lung Assist ECCO2R: Extracorporeal Carbon Dioxide Removalvv-ECMO: Venovenous Extracorporeal Membrane Oxygenation va-ECMO: Venoarterial Extracorporeal Membrane Oxygenation*at least 3 completed months, **e.g. positioning in a rotating or.