Table 6 Results of determination of SAC and VAL in Enteresto® tablets and the application of standard addition technique in human plasma using the proposed HPLC method.

From: A sensitive green HPLC-fluorescence method for simultaneous analysis of sacubitril and valsartan in pure forms, pharmaceutical dosage form and human plasma

Pharmaceutical formulation

Component

Taken (µg/mL)

Found %*

± SD

Standard addition technique

Pure added (µg/mL)

Pure found (µg/mL)

Recovery%*

Enteresto® tablets Batch no. T0005

SAC

0.96

101.46 ± 0.18

0.77

0.78

101.87

0.96

0.97

100.65

1.15

1.17

101.84

Mean ± SD

101.45 ± 0.62

VAL

1.00

102.84 ± 0.91

0.80

0.81

101.13

1.00

1.01

100.85

1.20

1.22

101.27

Mean ± SD

101.08 ± 0.15

  1. *Average of 3 determinations.
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