Table 1 Mutation rates (%) for the nine-gene panel in the TCGA and DFCI datasets. Mutation rates are shown separately for non-hypermutated and hypermutated cases. The Total columns represent the overall mutation rates across all samples, regardless of hypermutation status. Values indicate the percentage of samples in each dataset with a somatic mutation in the corresponding gene.
Gene | Non-hypermutated | Hypermutated | Total | |||
|---|---|---|---|---|---|---|
TCGA | DFCI | TCGA | DFCI | TCGA | DFCI | |
ACVR2A | 0.4 | 2.3 | 46.2 | 27.7 | 7.8 | 6.95 |
APC | 71.0 | 58.6 | 44.6 | 21.4 | 66.7 | 51.9 |
BRAF | 2.8 | 9.86 | 45.4 | 60.7 | 9.7 | 19.1 |
CTNNB1 | 1.0 | 1.0 | 8.5 | 2.7 | 2.2 | 1.3 |
KRAS | 41.3 | 30.2 | 21.5 | 9.8 | 38.1 | 26.5 |
NRAS | 5.6 | 4.1 | 3.1 | 1.8 | 5.2 | 3.7 |
PIK3CA | 16.3 | 15.3 | 34.6 | 25.9 | 19.3 | 16.8 |
RNF43 | 0.0 | 1.8 | 40.0 | 40.1 | 6.5 | 8.7 |
TP53 | 56.3 | 50.6 | 25.4 | 22.3 | 51.3 | 45.7 |