Table 1 Mutation rates (%) for the nine-gene panel in the TCGA and DFCI datasets. Mutation rates are shown separately for non-hypermutated and hypermutated cases. The Total columns represent the overall mutation rates across all samples, regardless of hypermutation status. Values indicate the percentage of samples in each dataset with a somatic mutation in the corresponding gene.

From: A set cover algorithm identifies minimal circulating tumour DNA sequencing targets for colorectal cancer detection

Gene

Non-hypermutated

Hypermutated

Total

TCGA

DFCI

TCGA

DFCI

TCGA

DFCI

ACVR2A

0.4

2.3

46.2

27.7

7.8

6.95

APC

71.0

58.6

44.6

21.4

66.7

51.9

BRAF

2.8

9.86

45.4

60.7

9.7

19.1

CTNNB1

1.0

1.0

8.5

2.7

2.2

1.3

KRAS

41.3

30.2

21.5

9.8

38.1

26.5

NRAS

5.6

4.1

3.1

1.8

5.2

3.7

PIK3CA

16.3

15.3

34.6

25.9

19.3

16.8

RNF43

0.0

1.8

40.0

40.1

6.5

8.7

TP53

56.3

50.6

25.4

22.3

51.3

45.7