Table 3 Determination of Safinamide mesylate (SAF) in Parkimedine® tablets using the proposed chemometric methods and the results of standard addition technique.
Pharmaceutical formulation | Proposed chemometric methods | Standard addition technique | ||||
|---|---|---|---|---|---|---|
Drug | Models | Claimed (µg/mL) | %Found ± SDa | Pure added (µg/mL) | %Recovery of the pure addedb | |
Parkimedine® tablets(Each tablet was Labelled to Contain 100 mg SAF) | SAF | PCR | 6 | 98.55 ± 0.987 | 3.0 | 98.67 |
6.0 | 100.61 | |||||
12.0 | 102.05 | |||||
Mean ± SD | 100.44 ± 1.692 | |||||
PLS | 98.92 ± 0.947 | 3.0 | 99.66 | |||
6.0 | 100.90 | |||||
12.0 | 102.15 | |||||
Mean ± SD | 100.90 ± 1.245 | |||||
siPLS | 100.33 ± 0.722 | 3.0 | 101.99 | |||
6.0 | 102.05 | |||||
12.0 | 99.13 | |||||
Mean ± SD | 101.06 ± 1.664 | |||||
