Fig. 3
From: Developmental toxicity of fluconazole and 1,2,4-triazole in Xenopus laevis
Detailed analysis of malformation incidence in embryos treated with FLU and TRI. (A–B) Bar plots show the percentage of embryos with developmental malformations at 120 hpf across increasing concentrations of FLU and TRI. While FLU caused a plateau in malformation incidence (~ 40%) starting from 1 µg/L, TRI exhibited a gradual, concentration-dependent increase in malformations, reaching ~ 25% at 1000 µg/L. Data represent 24 embryos per each experimental condition. Red lines represent type of dependency. (C) Incidence of malformations in Xenopus laevis embryos following exposure to FLU and TRI. The table presents the incidence of the main morphological alterations observed. Color intensity indicates a qualitative assessment of severity (dark gray: severe; gray: moderate; light gray: mild). Representative images of each phenotype are highlighted on the left. FLU exposure had a stronger effect on Xenopus development compared to TRI.
