Table 2 Odds ratios (95% confidence intervals) for associations between whole blood and urinary selenium concentrations and prostate cancer among Nigerian men.

From: A U-shaped association between blood selenium levels and prostate cancer: findings of a case-control study among Nigerian men

Variables

Unadjusted model

Model A

Model B

Model C

Blood selenium (µg/L)

 Ln-transformed blood selenium

1.29 (0.47, 3.53)

1.72 (0.59, 5.02)

1.52 (0.42, 5.52)

2.22 (0.57, 8.56)

 Tertile 1 (< 116)

Reference

Reference

Reference

Reference

 Tertile 2 (117–134)

0.31 (0.14, 0.70)*

0.33 (0.14, 0.79)*

0.35 (0.13, 0.89)

0.43 (0.17, 1.12)

 Tertile 3 (> 135)

1.15 (0.60, 2.21)

1.45 (0.78, 1.67)

1.52 (0.67, 3.44)

2.01 (0.88, 4.77)

Urine selenium (µg/L)

 Ln-transformed urine selenium

0.79 (0.55, 1.13)

0.80 (0.55, 1.17)

0.55 (0.30, 1.00)

0.58 (0.31, 1.06)

 Tertile 1 (< 14.70)

Reference

Reference

Reference

Reference

 Tertile 2 (14.71–28.30)

1.13 (0.57, 2.21)

1.05 (0.51, 2.16)

0.88 (0.36, 2.14)

0.78 (0.32, 1.93)

 Tertile 3 (> 28.31)

0.63 (0.30, 1.30)

0.60 (0.28, 1.32)

0.40 (0.13, 1.22)

0.42 (0.14, 1.33)

Creatinine-adjusted urine selenium (µg/g creatinine)

 Ln-transformed urine selenium

1.25 (0.88, 1.79)

1.14 (0.78, 1.67)

0.62 (0.32, 1.18)

0.63 (0.33, 1.22)

 Tertile 1 (< 14.71)

Reference

Reference

Reference

Reference

 Tertile 2 (14.72–23.22)

0.61 (0.28, 1.31)

0.52 (0.23, 1.19)

0.36 (0.14, 0.95)

0.38 (0.14, 1.01)

 Tertile 3 (> 23.23)

1.52 (0.77, 2.97)

1.31 (0.64, 2.66)

0.78 (0.30, 2.05)

0.80 (0.30, 2.12)

  1. ORs = Odds ratios; *= significant association at p < 0.0163 (Bonferroni adjustment); Model A was adjusted for ln-transformed age, ln-transformed body mass index, major occupation, smoking frequency and family history of prostate cancer. Model B was further adjusted for ln-transformed blood and urine zinc, copper, manganese and iron concentrations, respectively.
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