Fig. 5 | Scientific Reports

Fig. 5

From: Synthesis, H2S releasing properties, antiviral and antioxidant activities and acute cardiac effects of nucleoside 5′-dithioacetates

Fig. 5

H2S releasing curves measured by H2S selective sensor (A–F, 10% w/v) and two possible routes of H2S release from 5′-dithioacetyl nucleosides under physiological conditions (G). (A) Compound 22 (0.31 mM); (B) compound 24 (0.29 mM) (inset: first 60 min); (C) compound 27 (0.28 mM); (D) compound 29 (0.32 mM); (E) compound 30 (0.32 mM); (F) the blue curve shows the H2S release of compound 24 (0.31 mM), the orange curve shows the H2S release of NaHS (0.1 mg in 5 mL of distilled water, 0.36 mM) and the green curve shows the H2S release of GYY4137 (0.5 mg in 5 mL of medium, 0.27 mM); (G) H2S release (a) by cysteine-mediated transesterification, (b) by aspecific esterase-catalyzed hydrolysis.

Back to article page