Table 1 Anti-SARS-CoV-2 activities (EC50), cytotoxicity in Calu-3 cells (CC50) and virus yield reduction assay for nucleoside 5′-dithioacetates.

From: Synthesis, H2S releasing properties, antiviral and antioxidant activities and acute cardiac effects of nucleoside 5′-dithioacetates

Compound

EC50 ± SE [µM]

CC50 ± SE [µM]

SARS-CoV-2 titer reduction [log10 PFU/mL]

22

> 1000

> 1000

0.02

24

173 ± 24

~ 1000

0

27

158 ± 34

> 1000

0.38

29

> 1000

> 1000

0.13

30

621 ± 181

764 ± 82

0.01

Remdesivir

0.5 ± 0.26

> 10

7.1

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