Table 2 Association between summary statistics of each cluster of POPs obtained by hierarchical variable clustering and ER-positive breast cancer risk in the E3N cohort (N = 66,722).

From: Application of three statistical approaches to explore effects of dietary intake of multiple persistent organic pollutants on ER-positive breast cancer risk in the French E3N cohort

 

AP0: Unadjusted

AP1: Adjusted

 

HR [95% CI]

p-value

HR [95% CI]

p-value

Cluster 1 summary statistic, for 1 SD increase

1.06 [1.03–1.09]

< 0.001

1.04 [0.97–1.12]

0.219

Cluster 2 summary statistic, for 1 SD increase

1.03 [0.99–1.06]

0.111

0.96 [0.91–1.02]

0.164

Cluster 3 summary statistic, for 1 SD increase

1.02 [0.99–1.05]

0.184

0.99 [0.93–1.06]

0.856

Cluster 4 summary statistic, for 1 SD increase

1.05 [1.01–1.08]

0.005

1.00 [0.92–1.10]

0.923

Cluster 5 summary statistic, for 1 SD increase

0.98 [0.95–1.02]

0.325

0.99 [0.96–1.02]

0.489

Cluster 6 summary statistic, for 1 SD increase

1.02 [0.98–1.05]

0.318

0.99 [0.96–1.03]

0.647

Cluster 7 summary statistic, for 1 SD increase

1.04 [1.01–1.08]

0.004

1.03 [0.98–1.08]

0.281

Cluster 8 summary statistic, for 1 SD increase

1.04 [1.01–1.07]

0.008

1.00 [0.95–1.05]

0.972

Cluster 9 summary statistic, for 1 SD increase

1.04 [1.01–1.07]

0.021

1.00 [0.96–1.05]

0.981

Cluster 10 summary statistic, for 1 SD increase

1.01 [0.98–1.04]

0.537

0.98 [0.94–1.02]

0.243

Cluster 11 summary statistic, for 1 SD increase

1.03 [1.00–1.06]

0.082

1.02 [0.98–1.05]

0.404

  1. Hazard ratios (HR) and 95% confidence interval (CI) are estimated by Cox univariable and multivariable regression models. Values in bold are significant (i.e., p<0.05).
  2. SD: standard deviation.
  3. AP0: Use of age as the time-scale (years), without stratification or adjustment variables.
  4. AP1: Use of age as the time-scale (years), stratification of the baseline hazard on birth generation (≤ 1930; (1930–1935]; (1935–1940]; (1940;1945]; >1945), adjustment on school education level (< 12 years; 12 to 14 years; >14 years), smoking status (non-smoker; former smoker; current smoker), body mass index (< 18.5; [18.5–22.5); [22.5–25); [25–30); ≥30 kg/m2; missing values), parity and age at FFTP (nulliparous; one or two children and age at FFTP < 30; more than two children and age at FFTP < 30; age at FFTP ≥ 30), cumulated duration of previous breastfeeding (no breastfeeding: less than 6 months of breastfeeding; at least 6 months of breastfeeding), utilization of contraceptive pill (ever; never), menopausal status and recent use of MHT (pre-menopaused, menopaused with recent use of MHT; menopaused without recent use of MHT, menopaused and missing data on recent used of MHT), physical activity (continuously in metabolic equivalents of task-hour/week), daily alcohol intake (continuously in g of ethanol/day), daily lipids intake (continuously in g/day), and daily total energy intake except from alcohol and lipid (continuously in kcal/day), and mutual adjustment of each cluster summary statistic to each other.
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