Table 3 Association between principal components of POPs obtained by PCA and ER-positive breast cancer risk in the E3N cohort (N = 66,722).

From: Application of three statistical approaches to explore effects of dietary intake of multiple persistent organic pollutants on ER-positive breast cancer risk in the French E3N cohort

 

AP0: Unadjusted

AP1: Adjusted

 

HR [95% CI]

p-value

HR [95% CI]

p-value

Component 1, for 1 SD increase

1.05 [1.01–1.08]

0.005

1.02 [0.97–1.07]

0.441

Component 2, for 1 SD increase

1.04 [1.01–1.08]

0.015

1.03 [0.98–1.07]

0.211

Component 3, for 1 SD increase

1.01 [0.98–1.04]

0.659

1.00 [0.97–1.04]

0.776

Component 4, for 1 SD increase

0.98 [0.95–1.01]

0.203

0.99 [0.96–1.02]

0.487

Component 5, for 1 SD increase

1.00 [0.97–1.04]

0.786

1.00 [0.97–1.03]

0.965

  1. Hazard ratios (HR) and 95% confidence interval (CI) are estimated by Cox multivariable regression models. Values in bold are significant (i.e., p<0.05).
  2. SD: standard deviation.
  3. AP0: Use of age as the time-scale (years), without stratification or adjustment variables.
  4. AP1: Use of age as the time-scale (years), stratification of the baseline hazard on birth generation (≤ 1930; (1930–1935]; (1935–1940]; (1940;1945]; >1945), adjustment on school education level (< 12 years; 12 to 14 years; >14 years), smoking status (non-smoker; former smoker; current smoker), body mass index (< 18.5; [18.5–22.5); [22.5–25); [25–30); ≥30 kg/m2; missing values), parity and age at FFTP (nulliparous; one or two children and age at FFTP < 30; more than two children and age at FFTP < 30; age at FFTP ≥ 30), cumulated duration of previous breastfeeding (no breastfeeding: less than 6 months of breastfeeding; at least 6 months of breastfeeding), utilization of contraceptive pill (ever; never), menopausal status and recent use of MHT (pre-menopaused, menopaused with recent use of MHT; menopaused without recent use of MHT, menopaused and missing data on recent used of MHT), physical activity (continuously in metabolic equivalents of task-hour/week), daily alcohol intake (continuously in g of ethanol/day), daily lipids intake (continuously in g/day), and daily total energy intake except from alcohol and lipid (continuously in kcal/day), and mutual adjustment of each principal component to each other.
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