Fig. 4

NTN1 Mutation analysis in various tumors. (a) Genetic alteration frequency of NTN1 in pan cancer (green, Mutation; purple, structural variant; red, amplification; blue, deep deletion; gray, multiple alterations). (b) The 3D view of the NTN1 protein. (c) Mutation sites of NTN1. (d) Mutation counts of NTN1. (e) The correlation of NTN1 expression and copy-number values. (f) NTN1 expression difference among different copy-number alterations. (g) The top ten genes with significant difference in mutation rate between NTN1 altered and unaltered groups (red, altered groups; bule, unaltered groups). (h) The waterfall plot showed the mutation profile of NTN1 and its related genes across different cancer types. The tumor mutation burden is marked on the top of the plot. The names of cancer types are located on the right side of the bottom, with different mutation types on the left side. The names of genes are marked on the left. The stacked column chart on the right represents the frequency of SNVs mutation types, with different colors indicating various SNVs mutation types. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)