Table 2 DoE-Generated optimization of HAPNPs.

From: QbD-Driven preparation, characterization, and pharmacokinetic investigation of daidzein-l oaded nano-cargos of hydroxyapatite

Run

Factor 1

Factor 2

Factor 3

Response 1

Response 2

pH of Ammonium Phosphate

pH of Calcium Nitrate

Dilution Factor

Particle Size

nm

PDI

%

1

11

10

0.5

210.26

0.3956

2

12

11

0.7

202.93

0.3862

3

10

12

0.6

129.07

0.3544

4

11

12

0.7

167.12

0.3454

5

11

11

0.6

152.04

0.3941

6

12

12

0.6

118.06

0.2843

7

12

10

0.6

240.7

0.3356

8

11

12

0.5

194.18

0.3587

9

12

11

0.5

239.08

0.3589

10

11

11

0.6

139.04

0.3641

11

11

10

0.7

222.86

0.3939

12

10

10

0.6

228.26

0.3706

13

11

11

0.6

163.04

0.3641

14

11

11

0.6

140.04

0.3541

15

10

11

0.5

225.44

0.3852

16

11

11

0.6

210.04

0.3641

17

10

11

0.7

307.12

0.4129

Back to article page