Table 3 DoE- generated optimization of DZHAPNPs.

From: QbD-Driven preparation, characterization, and pharmacokinetic investigation of daidzein-l oaded nano-cargos of hydroxyapatite

Run

Factor A

Factor B

Factor C

Response 1

Response 2

Response 3

HAP: DZ

Dispersion Volume (mL)

Loading Time(hr)

Particle Size (nm)

Entrapment

(%)

Zeta Potential (mV)

1

3

40

12

142.15

66.54

−18.88

2

2

40

18

140.01

72.99

−20.39

3

2

40

18

139.65

78.29

−20.42

4

2

40

18

138.99

76.99

−21.51

5

2

30

12

136.9

63.91

−18.33

6

1

30

18

140.47

67.13

−17.45

7

3

40

24

143.17

63.13

−19.04

8

2

50

12

139.59

65.89

−20.07

9

3

30

18

140.01

68.54

−19.45

10

2

30

24

139.91

76.51

−20.3

11

2

40

18

138.97

68.29

−21.42

12

2

40

18

139.65

79.05

−20.6

13

1

50

18

136.28

65.85

−19.64

14

2

50

24

129.2

87.22

−22.72

15

1

40

12

148.73

63.46

−19.18

16

1

40

24

139.62

78.47

−20.31

17

3

50

18

134.58

66.18

−18.09