Fig. 3
From: Attention-based deep learning for accurate cell image analysis
The feature distance and angle characterize a compound’s toxicity and its dose-dependency. (a, b) The feature cosine value and mahalanobis distance for compounds when compared with DMSO. The x-axis corresponds to the compounds, while the y-axis denotes the cosine value. Circular dots represent toxic compounds, and upward triangles represent non-toxic compounds. The colors green, blue, yellow, purple, brown, and red respectively correspond to compound concentrations of 0.04 µM, 0.12 µM, 0.36 µM, 1.11 µM, 3.33 µM, and 10.00 µM. (c) The frequency distribution histogram of the absolute differences between true IC50 values and their predicted counterparts. From left to right, the sequence is as follows: X-Profiler, DeepProfiler, and CellProfiler, with the predicted IC50 values derived from the mahalanobis distance calculation. (d) The fitted curves for the IC50 values of the compound carvedilol. From left to right, the sequence is as follows: X-Profiler, DeepProfiler, and CellProfiler. The x-axis represents the logarithmic values of concentration, with the green and red vertical dashed line indicating the actual IC50 value and predicted IC50 value, respectively.
